Tag: TMP-SMX and warfarin

Trimethoprim-Sulfamethoxazole and Warfarin: How This Combo Raises INR and Risks Bleeding

Trimethoprim-sulfamethoxazole (Bactrim) can cause dangerous INR spikes in people taking warfarin, raising bleeding risk. Learn why this interaction happens, how to prevent it, and what to do if your INR rises.